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Dotfix 1mg Tablet 1 Strip
Dotfix 1 is indicated for:
✔️ Gout management – Helps prevent and treat flare-ups.
✔️ Hyperuricemia treatment – Reduces uric acid levels in the blood.
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✅ Description:
Dotfix 1 is an effective selective urate reabsorption inhibitor designed to reduce uric acid levels and prevent gout attacks. However, patients must adhere to proper dosage adjustments and precautions to minimize risks and side effects. Regular monitoring, especially for kidney and liver function, is crucial for safe use. Always consult your doctor before making changes to your treatment regimen.
✔ Effectively lowers uric acid levels
✔ Selective inhibition for fewer side effects
✔ Monitored dosage adjustments for optimal safety
💙 For a healthier, gout-free life, consult your doctor before starting Dotfix 1
Safety Advices
Alcohol
UNSAFE
- Caution is advised when consuming alcohol while taking Dotfix 1. Consult your doctor for guidance.
Pregnancy
CONSULT YOUR DOCTOR
Should only be used if the benefits outweigh the risks. Consult your doctor.
Breastfeeding
CONSULT YOUR DOCTOR
The drug is excreted in breast milk. Consult your doctor before breastfeeding.
Driving
CAUTION
It is unknown whether Dotfix 1 affects driving ability. Do not drive if you experience dizziness, drowsiness, or difficulty concentrating.
CONSULT YOUR DOCTOR
- Dotfix 1 acts in the renal proximal tubule, and its effectiveness depends on kidney function.
- Alternative treatments should be considered for patients with severe renal impairment.
- Avoid use in patients with oliguria (low urine output) or anuria (no urine output).
CONSULT YOUR DOCTOR
Patients should undergo regular liver function tests, as serious liver damage has been observed with some other uricosuric drug
Relevant Products / প্রাসঙ্গিক পণ্য
✔️ Pharmacology
Dotinurad, the active ingredient in Dotfix 1, selectively inhibits URAT1, preventing the reabsorption of uric acid in the kidneys. This leads to increased uric acid excretion, thereby lowering serum uric acid levels. Unlike some other urate-lowering drugs, Dotfix 1 has minimal impact on other uric acid transporters like ABCG2, OAT1, and OAT3, making it highly selective and efficient.
✔️ Dosage & Administration
💊 Adults:
- Initial dose: 0.5 mg once daily.
- After 2 weeks: Increase to 1 mg daily.
- After 6 weeks: Increase to 2 mg daily (maintenance dose).
- Maximum dose: 4 mg per day.
💊 Children:
- Not recommended.
💊 Renal Impairment:
- Efficacy may be reduced in patients with renal dysfunction.
- Avoid use in patients with oliguria or anuria due to lack of expected effectiveness.
✔️ Potential Side Effects
🔹 Common side effects (1%–5% occurrence):
- Gouty arthritis flare-ups
- Limb discomfort
🔹 Rare side effects (<1% occurrence):
- Loose stools
- Increased gamma-glutamyl transferase (γ-GTP)
- Joint pain (arthralgia)
- Kidney stones (nephrolithiasis)
- Calcium deposits in kidneys (nephrocalcinosis)
- Elevated urinary β2-microglobulin levels
- Increased blood creatinine levels
- Elevated urine albumin/creatinine ratio
- Presence of urine albumin
Note: If severe side effects occur, consult your doctor immediately.
✔️ Missed Dose:
- Take the missed dose as soon as you remember.
- If it’s close to the next scheduled dose, skip the missed one.
- Never double the dose.
✔️ Important Considerations
- Gout attacks may initially worsen when starting urate-lowering therapy due to a rapid drop in uric acid levels.
- If a gout flare-up occurs before starting Dotfix 1, wait until symptoms subside before initiating treatment.
- If a gout attack occurs during treatment, continue taking Dotfix 1 at the same dose. Additional medications (e.g., colchicine, NSAIDs, or corticosteroids) may be needed for symptom management.
✔️ Drug Interactions
⚠️ Medications that may reduce the effectiveness of Dotfix 1:
1️⃣ Pyrazinamide (Anti-TB drug):
- May suppress uric acid excretion, potentially weakening the effect of Dotfix 1.
2️⃣ Salicylates (Aspirin & related drugs):
- These medications may counteract the uric acid-lowering effects of Dotfix 1 by reducing uric acid excretion.
💡 Consult your doctor before using Dotfix 1 with these medicationsgs.
Disclaimer:
ePharma sole intention is to ensure that its consumers get proper
information as musch as possible. Although we do not guarantee the
accuracy and the completeness of the information that provided and
here information is for informational purposes only.
The information contained herein should NOT be used as a substitute
for the advice of a qualified physician. This may not cover
everything about particular health conditions,
lab tests, medicines, all possible side effects, drug interactions,
warnings, alerts, etc. Please consult your healthcare professional
and discuss all your queries related to any disease or medicine. We
intend to support, not replace, the doctor-patient relationship.
